The limited edition Drones World Tour MBC-1 is signed by band members Matt, Dom and Chris.
The guitar is a limited edition and one of only 80 produced in the Mansons Guitar Works Factory by Tim Stark, Hugh Manson and Co Owner Adrian Ashton.
The money raised will go to two charities.
The private auction starts 20th April and will go on until 2nd June.
Pro skydiver dies at Devon airfield
Third fatality in less than a year
Torquay United searching for new manager
National League South side sacks Paul Wotton
Torbay councilors clash over street cleaning and signage
Some were told to grow up
Pothole reports in Plymouth triple
The weather has played havoc
Electric cars add to hazards in busy Paignton street
'Only dogs can hear them'
Armada Way revamp will be shining light at end of tunnel
Opinion: From building site to regeneration catalyst
