Junction 29 of the M5 and the westbound carriageway of the A30 will be closed for five nights from tonight.
The restrictions will apply from 8 pm until 6 am while resurfacing and other work is carried out.
Further overnight closures are planned for later this month and during September.
Frustration over cancelled Exeter elections
Opponents unite to demand Exeter elections
Push for fair education funding heading to Westminster
Devon politicians will head to the capital
19 Plymouth seats up for grabs in May elections
Plymouth won't postpone them
Two WW2 bombs safely removed in Devon
Cordons lifted in Exmouth and Plymouth
New Exeter City winger joins from Sunderland
Timur Tutierov on loan until summer
Plea for help as Devon pubs face crisis
'The trade is hunkering down and hoping for the best'
