It follows their narrow 20 -24 defeat by the Leicester Tigers last Saturday.
Phil Dollman and Jack Nowell both return for the first time this season, taking over from Ceri Sweeney and Jack Arnott.
Two changes have been made to the starting line-up with Ben Moon coming in for Carl Rimmer, while Damian Welch comes in instead of Ryan Caldwell.
Debate over Exeter and Plymouth elections taking place
Plan for 35 village homes slammed as “overdevelopment”
'Red' alert in Cornwall as strong winds become risk to life
Grit situation 'risks injuries' in Cranbrook
Residents to quiz council on roundabout upgrades
North Devon foster carers could be exempt from council tax
